Glucocorticoids enhance acid activation of the Na+/H+ exchanger 3 (NHE3).

TRANSLATIONAL PHYSIOLOGY Glucocorticoids acutely increase cell surface Na /H exchanger-3 (NHE3) by activation of NHE3 exocytosis

Bobulescu, I. Alexandru, Vangipuram Dwarakanath, Lixian Zou, Jianning Zhang, Michel Baum, and Orson W. Moe. Glucocorticoids acutely increase cell surface Na /H exchanger-3 (NHE3) by activation of NHE3 exocytosis. Am J Physiol Renal Physiol 289: F685–F691, 2005. First published June 7, 2005; doi:10.1152/ajprenal.00447.2004.—Glucocorticoids have important effects on renal function, including the ...

Glucocorticoids acutely increase cell surface Na+/H+ exchanger-3 (NHE3) by activation of NHE3 exocytosis.

Glucocorticoids have important effects on renal function, including the modulation of renal acidification by the major proximal tubular Na(+)/H(+) exchanger, NHE3. While the chronic effect of glucocorticoids is considered to be primarily at the transcriptional level, with increases in NHE3 mRNA and protein expression driving increased transport activity, the mechanisms by which glucocorticoids ...

Acute activation of Na+/H+ exchanger NHE3 by dexamethasone correlates with activation of SGK1 and requires a functional glucocorticoid receptor

Characterization of the regulation of renal Na+/H+ exchanger NHE3 by insulin.

Insulin receptors are widely distributed in the kidney and affect multiple aspects of renal function. In the proximal tubule, insulin regulates volume and acid-base regulation through stimulation of the Na(+)/H(+) exchanger NHE3. This paper characterizes the signaling pathway by which insulin stimulates NHE3 in a cell culture model [opossum kidney (OK) cell]. Insulin has two distinct phases of ...

Acute activation of NHE3 by dexamethasone correlates with activation of SGK1 and requires a functional glucocorticoid receptor.

Glucocorticoids stimulate the intestinal absorption of Na(+) and water partly by regulation of the Na(+)/H(+) exchanger 3 (NHE3). Previous studies have shown both genomic and nongenomic regulation of NHE3 by glucocorticoids. Serum and glucocorticoid-inducible kinase 1 (SGK1) has been shown to be part of this cascade, where phosphorylation of NHE3 by SGK1 initiates the translocation of NHE3 to t...